LA Galaxy's Zlatan Ibrahimovic has started the 2019 MLS season in scintillating form, netting six times in just five games. The Swedish striker looks set to make this the season the MLS Cup returns to Los Angeles, so favour him to continue his stunning form and score the first goal.
The first ever meeting between these sides sees Real Salt Lake travel to Nippert Stadium aiming for their first away win this year. Both clubs have had mediocre starts to the season and sit on seven points apiece after as many games, so with little separating the teams, favour a stalemate here.
It will be fascinating to see how both teams line up and approach this match after their classic Champions League clash on Wednesday. There is every chance that Spurs will rest some players after progressing while City's urgency should see them pick up another win to boost their title hopes.
Kolkata Knight Riders have lost their last three matches and they need to win this match desperately as do the Royal Challengers Bangalore. KKR will take heart from the fact that they have dominated recent meetings against RCB, winning their last five.
Everton's home form has been strong of late and despite the slip-up against Fulham last weekend, they will raise their game again to welcome United to Goodison. Solskjaer's men are struggling right now after a busy schedule and they may find themselves up against it once again here.
Liverpool's relentless pursuit of the Premier League continues as they make the trip to South Wales to face a Cardiff side fighting for survival. Warnock's men will battle for every ball but ultimately one would expect Liverpool's pace and quality to wear them down and pick up a tenth win in a row.
Melbourne City's away form has been poor in recent weeks having lost five of their last seven road trips. They make the long trip to Wellington here against a Phoenix team that are strong at home, and the hosts will be confident of picking up all three points.
Brighton are becoming increasingly desperate now after being dragged back into the relegation fight after losing their last four games without scoring. Wolves looked flat last week, but they should match up well stylistically against Brighton and they can plunge the visitors into further trouble.
Both of these teams come into this match off excellent results and they know that three more points will virtually seal survival in the Premier League for another season. They have enough margin for error, though, which may see them play with freedom and this could be more open than many expect.
Neither of these teams has anything but pride to play for and planning has already started for next season which could see changes to their regular starting line-ups. Brisbane Roar's matches often contain plenty of goals, while the Jets have an excellent record in Brisbane which may continue here.
It is difficult to have any real confidence in predicting West Ham's matches as it depends which version of them turns up. Leicester are playing some good football despite the reversal last week and that should make for an open and entertaining game with plenty of goals in it.
Huddersfield's form has declined by the game as they lose motivation while their impending relegation plays out. With boss Jan Siewert planning for next season and giving game time to some younger players, expect Watford to take advantage and inflict another defeat on the Terriers.
Despite having plenty of their regular starters available, the Mariners' difficult season cannot end quick enough for them as they continue to lose match after match. While the Wanderers equally have nothing to play for, they are ending the season with some good displays which gives them the edge.
Bournemouth continue to be one of the most unpredictable teams in the league as they come off a 5-0 win at Brighton. That should give them a boost in confidence and while they face a Fulham team that beat Everton last week, that win should not mask the visitors' major deficiencies.