Roma were outstanding when they hammered Plzen in Rome 5-0 earlier in the group stage but the two teams have taken different paths since then. The visitors are struggling with form without Dzeko, while Plzen are playing well right now so do not rule out the hosts springing a surprise.
United know that they have to win to have any chance of finishing top of the group but that will not really come into Mourinho's thoughts when selecting the team. He will rotate with the upcoming Liverpool game in mind and that will likely lead to a disjointed and low scoring match.
Shakhtar are playing in Kyiv this time due to the political unrest in Ukraine so that may upset their preparations somewhat. They are typically strong when playing at home but the change in venue may suit Lyon who will also enjoying playing on the counter and expect both teams to score here.
CSKA do not travel particularly well and after having lost at home to Plzen on matchday five, their confidence cannot be great as they head to the Bernabeu. Real are in fine form and even if they do rotate, they should still be able to canter to victory.
Both of these teams know only one way of playing and that is to attack. That could make Hoffenheim ripe for a heavy beating here as they can be a little naive at times, and Guardiola's wounded men will be determined to respond immediately to the defeat at Chelsea on Saturday.
These two teams are just playing for pride now and both teams are under a bit of pressure as they have been experiencing below-par campaigns by their high standards. Benfica will be confident though against an AEK team who have yet to pick up a point in the Champions League this season.
Other than top spot, there is not too much riding on this game but both teams will be keen to maintain their recent momentum.
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This is a vital match in the race for the play-offs with these two teams direct competitors for a play-off place and this being their final matches. The Giants sit in the final play-off berth and are currently just four points above Paarl Rocks so they know this match is just as important for them as it is their opponents.
All the urgency and motivation coming into match is with the Tshwane Spartans and they need to keep winning to have any chance of reaching the Eliminator. Their bowling unit has been one of the best in the tournament...
It is virtually impossible to have any confidence in this ridiculously fragile West Indies’ side at the moment such is their form and inability to produce with the bat especially. They have more quality in this one-day side than their Test team but they still failed to produce in the first ODI where they were completely outplayed.
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The visitors have more to play for here as they have a chance of qualifying for the Europa League while Schalke are confirmed in second place. The hosts however will be keen to bounce back from their derby loss at the weekend and should have too much for Lokomotiv even if they do rotate.
Monaco’s form remains woeful and even though Dortmund will likely rest some players here, they should still have far too much quality for what is essentially a combination of Monaco’s fringe and youth players. A comfortable away win and one to add to accumulators.