Man City's pursuit of the quadruple continues and this is another key match for them. Guardiola has rotated significantly in recent matches but he will field something close to his strongest team here and they should ultimately have far too much for an average Schalke side.
This match is arguably the toughest Round of 16 match to call as these two heavyweights collide. Their team selections for this first leg will give a big indication of how brave and ambitious each coach is feeling but it is hard to see too many goals in what could be a classically cagey first leg.
Lyon have picked up some impressive results at times this season with the win at Man City a particular highlight and they will take confidence from that. They will play primarily on the counter attack and they can cause this Barcelona defence problems so expect goals at both ends in this one.
Despite this being a first leg tie which are often cautious and cagey, the attacking nature of both these teams makes that unlikely. The fact Van Dijk is missing for Liverpool will weaken them significantly and Bayern are struggling to keep clean sheets so expect plenty of goals at Anfield.
Sydney should stabilise their wobble and get their title challenge back on track here as they face a side who have lost their nine away games. The hosts have won their last five home matches and they have been leading at half-time in three of those so the double result market stands out.
Internazionale have won their last two matches 1-0 and they have secured 1-0 victories in two of their last four home league matches. Sampdoria, and more importantly Fabio Quagliarella, have failed to score in their last two league games including a 1-0 loss to Frosinone last weekend, so a resolute Inter victory looks likely.
Napoli have won their last five home league matches, not conceding in three, and they have kept clean sheets in their last three Serie A games. Torino, meanwhile, have not won any of their last six Serie A matches, failing to score in three of these games. Napoli look good for a shutout on Sunday.
Ajax were three minutes away from holding Real Madrid to a 1-1 draw in their midweek Champions League encounter, only to be denied by a late winner for Los Blancos. Erik ten Hag will be confident of his side bouncing back emphatically with a convincing win over NAC Breda.
It would take a dramatic turnaround in form for Girona to claim any reward at Santiago Bernabeu and a repeat of Real Madrid's 3-1 win over Eusebio Sacristan's side in the Cope del Rey in January seems more likely. Real won 2-1 at Ajax on Wednesday, but fatigue should not be an issue.
There have been four or more goals in four of PSV Eindhoven's last five Eredivisie matches and in two of those they have been held to 2-2 draws. It has been a somewhat shaky few weeks for the league leaders who have dropped points at Emmen and Utrecht but they will expect to win at Heerenveen.
This could wind up being an entertaining match, given that the score was 3-2 to Swansea when the sides met earlier this season. Over 2.5 goals has landed in seven of Swansea's last eight home FA Cup matches and that looks a nice angle into what is a tricky tie from which to pick the match winner.
Doncaster Rovers have been quick starters in the FA Cup this season, having scored the opening goal in their four cup matches. Although they are unlikely to pull off an upset against Crystal Palace, they should be a bit of value to cause a stir by hittng the net first on Sunday.
This should be a high-quality encounter given that Bristol City have racked up nine consecutive victories in all competitions and Wolves sit seventh in the Premier League after a stellar campaign so far. A draw after 90 minutes may be the safest play in a match which could go to extra-time.
Perth have their sights firmly set on the title now after beating their nearest rivals and they will be licking their lips at the prospect of facing a depleted Roar side. The visitors produced a shock win against Sydney FC recently but this should be a comfortable home win for the leaders.