While Leganes look safe, Celta de Vigo need to fight for every point they can get and they have been battling bravely, losing just one of their last six La Liga matches. They will not make life easy for Leganes and a similar encounter to their score draws at Huesca and Espanyol could ensue.
Barcelona's title celebrations were delayed after Atletico Madrid beat Valencia in midweek, but Barca will be confident of clinching back-to-back titles with a big home win over Levante. The visitors have conceded 12 goals in their last six games and will struggle to contain the champions.
Twice pegged back by Valencia in midweek, second-placed Atletico Madrid pulled through to win 3-2 and restore their seven-point lead over Real Madrid. With seven wins in their last seven league games against Real Valladolid and three clean sheets in the last four, this should be an easy home win.
A first-half own goal earned Athletic Club a 1-0 win at Leganes last time out and kept their hopes of a top six La Liga finish very much alive. Seventh-placed Deportivo Alaves are just three points behind Athletic, but Abelardo's men are winless in their last six league games, so a home win looms.
Both clubs are enjoying unbeaten runs in Serie A, but Cagliari's away league form does not inspire confidence, with six defeats and a draw in their last eight games on the road. They could face a long evening against Roma's potent attack, whose tally of 36 home goals is second only to Juventus'.
Juventus got back on track after their Champions League exit to Ajax with a 2-1 success over Fiorentina, but they can expect another tight affair here. Internazionale have conceded just eight goals in 16 home league games and are the lowest scorers on home turf in the top half of the table.
Bologna have pulled five points clear of safety after just one defeat in their last seven games. They have scored 16 goals in the process and after three clean sheets in their last four home league games, another lock-out is likely, with Empoli taking only a point from their last three matches.
Perth Glory were beaten by Sydney last week but while they rested a number of players, they still produced a reasonably good display. They welcome a Wellington side who face the incredibly long trip West and the home side have to be favoured to end the regular season on a high note.
Melbourne Victory have had to contend with AFC Champions League commitments this week and that may see them deprioritise this match. Western Sydney Wanderers are unbeaten in their last four at home and they could get a result in what is ultimately a meaningless game for both teams.
It has been a hugely disappointing season for Newcastle Jets after such a positive one in 2018. They hammered Brisbane Roar 6-1 last week and can take advantage of Sydney's fatigue after a midweek trip to China to end the regular season with a win in what could be a high-scoring match.
It has been something of a stuttering end to the season for Melbourne City and they will want to produce a good performance before the play-offs begin. Against a Mariners team that has been woeful on their travels, City can build some momentum here by taking all three points.
Neither of these teams come into this match in particularly good form but there is plenty on the line in the race for fourth place. Defensively the two teams look vulnerable and with the attacking talent on show and urgency to win the game, that could make for a high-scoring game.
There is plenty on the line for Arsenal as they need to get back to winning ways as the race for fourth place is hotting up. Leicester will provide them with a stern test however and this should be a highly entertaining game with goals at both ends of the pitch in a game that could go either way.
Man City hammered Burnley 5-0 when they met in January but this Burnley team is in much-improved form right now. They will make it incredibly difficult for Guardiola's men here and they are more than capable of scoring so expect City to win, but not without one or two alarming moments.