While the focus is on Liverpool and Man City with regards to the title race, Tottenham have quietly gone about their business admirably and closed the gap at the top. They face a struggling Leicester team at Wembley and they should be able to keep the pressure on the top two with a win here.
This promises to be a fascinating clash at the Etihad as City face Chelsea who beat them in the reverse fixture. Guardiola's men have returned to winning ways in their last two matches but fatigue may be creeping in so this could very well be a tight and cagey affair with few goals.
Everton and Marco Silva will expect a hot reception at Vicarage Road against his former employers and that will likely serve as a big motivation for Watford. The Toffees are in the middle of a poor run of form and the hosts would love nothing more than to compound their miseries here.
This is an authentic relegation six-pointer as the ramifications of victory or defeat here would be huge. That could well lead to quite a negative and passive match with neither team prepared to take risks throughout so that makes the draw - potentially a goalless one - likely at St Mary's.
Liverpool are going through something of a wobble as a potential seven-point lead has been eaten up and they now sit behind Man City on goal difference with a game in hand. This is the perfect opportunity for them to bounce back against a struggling Bournemouth team and expect goals at Anfield.
Huddersfield's chances of survival remain slim and their fixtures do not get any easier as they now face Arsenal. The Gunners need to bounce back from defeat last weekend if they are to remain in the hunt for the top four and a comfortable win and clean sheet is on the cards.
Fulham's poor run of form has left them almost resigned to relegation now unless they can half United and Solskjaer's impressive form. That seems highly unlikely as United continue to thrive and have real momentum so expect another three points returning up North here.
Crystal Palace have shown a marked improvement in recent weeks to pull them away from danger and they will be confident after their win over Fulham. West Ham remain difficult to predict largely as their motivation appears wildly inconsistent but a low-scoring affair seems likely in this one.
Wolves are flying in the league right now and the win over Everton last week has seen them consolidate seventh place. Newcastle are scrapping for their lives still and they will likely approach this match cautiously with a clean sheet the priority which should lead to a low scoring match.
Brighton are coming off a goalless draw at home to Watford while Burnley have drawn their last three matches also. With plenty of pressure on to stay ahead of the bottom three, both teams seem content to grind out results at the moment and this could be another low-scoring stalemate.
The mood and atmosphere around Goodison is woeful at present with Marco Silva and the players under growing pressure. With confidence low, that does not bode well as they welcome City to Goodison and Guardiola's men should comfortably expose the fragile Everton defence and kill the game off early.
West Ham are in abysmal form right now having lost their last three matches although all of those came away from home. They should respond here and put in a better display, but they are coming up against the league leaders who will be desperate to bounce back themselves.
Man City simply have to win this match after slipping up at Newcastle in midweek as they welcome Arsenal to the Etihad. The Gunners have something of a defensive crisis on their hands which Guardiola's men should be able to expose and get the three points in convincing fashion.
Leicester have had some terrible results in recent weeks against lesser teams but have now drawn with Liverpool along with having beaten Man City and Chelsea in the last six weeks. They will be confident even against United and it promises to be another entertaining game with goals at both ends.