Sao Paulo vs Atletico Nacional Preview & Prediction | 2025 Copa Libertadores | Round of 16

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Brazilian giants Sao Paulo have an excellent chance to get into the quarter-finals of the CONMEBOL Copa Libertadores as they take on Colombian side Atletico Nacional.

Kick-off date/time:

How to watch on TV: UK – Not televised / US – Not televised

How to watch online: UK – Cannot be streamed / US – Fubo

Sao Paulo vs Atletico Nacional prediction

The first-leg of this CONMEBOL Copa Libertadores round of 16 tie saw Atletico Nacional and Sao Paulo share a goalless draw at Estadio Atanasio Girardot in Medellin last week.

Since then, Sao Paulo have shared an entertaining 2-2 draw with Sport Recife in their most recent outing at the weekend. They sit just outside of the top four in the Brazilian Serie A, with just one defeat in their last ten matches across all competitions. They now face an Atletico Nacional side that have since shared a 2-2 draw with Fortaleza in the Colombian Categoria Primera A Clausura at the weekend, to extend their own good run of form to just one loss in their last ten games.

These are two sides that appear evenly matched with similarly strong sides, but Sao Paulo will be expected to come out on top with their home advantage for this one.

Sao Paulo vs Atletico Nacional tip: Double chance – Sao Paulo to win or draw