Real Betis vs Lyon Preview & Prediction | 2025-26 UEFA Europa League | League Phase

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These are two of the favourites to go deep and win the UEFA Europa League as Real Betis face Olympique Lyonnais at La Cartuja on the outskirts of Seville this week.

Kick-off date/time: 6 November 2025 at 8:00 pm

How to watch on TV: UK – TNT Sports / US – Not televised

How to watch online: UK – discovery+ / US – Paramount+

Key stats

• The only previous UEFA competition matches between these teams were in the group stage of the 2013/14 UEFA Europa League, when a 0-0 draw in Spain on Matchday 1 was followed by a 1-0 home win for Lyon on Matchday 5.
• Betis are without a win in their last five UEFA competition matches against French teams (D3 L2).
• Betis have lost only one of their last 19 UEFA competition group/league matches at home (W11 D7).
• Betis have lost only one of their last ten UEFA competition matches (W4 D5).
• Betis have lost only three of their last 15 UEFA Europa League group/league matches (W9 D3).
• Lyon have lost only two of their last eight UEFA competition group/league matches against Spanish teams (W4 D2).
• Lyon have lost only two of their previous 35 UEFA Europa League group/league matches (W23 D10).
• Lyon have lost only one of their last 12 UEFA competition matches – all in the Europa League proper (W7 D4). They have won all three matches in the 2025/26 league phase without conceding a goal.

Real Betis vs Lyon prediction

Manuel Pellegrini’s 2025 UEFA Europa Conference League runners’ up Real Betis come into this one on the back of a 3-0 hammering of Real Mallorca in their most recent outing at the weekend. The Andalusians have suffered just two defeats in their 15 matches across all competitions so far this season.

They now face an Olympique Lyonnais side that are trying to be more effective under the management of Paulo Fonseca. Lyon most recently saw themselves tumble out of the top four in Ligue 1 after back-to-back domestic draws away to Paris FC, having been 3-0 up, and then against Stade Brest.

With home advantage, and the shaky recent form of Lyon as well as their own strong form, Real Betis are the team to be favoured with for this one.

Real Betis vs Lyon tip: Double chance – Real Betis to win or draw