Mainz vs Fiorentina Preview & Prediction | 2025-26 UEFA Conference League | League Phase

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These are two of the pre-tournament favourites from Europe’s so-called ‘big five’ leagues facing off as Bundesliga side Mainz 05 take on Serie A giants Fiorentina.

Kick-off date/time: 6 November 2025 at 5:45 pm

How to watch on TV: UK – TNT Sports / US – Not televised

How to watch online: UK – discovery+ / US – Paramount+

Key stats

• This is the first UEFA competition match between these teams and Mainz’s first against an Italian team.
• Mainz have won their last three UEFA competition matches.
• Mainz are unbeaten in their last seven UEFA competition matches at home (W4 D3).
• Mainz have kept four clean sheets in their last six UEFA competition matches.
• Mainz have scored in 13 of their last 14 UEFA competition matches.
• Fiorentina have won only three of their previous 12 UEFA competition matches against German teams (D3 L6).
• Fiorentina have won the most matches (24) and scored the most goals (97) in the UEFA Conference League (GS/LP to F). They need three goals to become the first team to score 100 goals in the UEFA Conference League competition proper.
• Fiorentina have lost only two of their previous 20 UEFA Conference League group/league matches (W13 D5).
• Fiorentina have won their previous four UEFA competition matches this season.
• Fiorentina have only failed to score in one of their previous 20 UEFA Conference League group/league matches.

Mainz vs Fiorentina prediction

Under the management of Bo Henriksen, Mainz come into this one on the back of back-to-back victories at the start of the league phase of the UEFA Europa Conference League. They have been woeful domestically, though, as they sit in the bottom two and the automatic relegation places in the Bundesliga.

They now face a Fiorentina side that have sacked Stefano Pioli after a woeful start to the campaign. I Viola have been runners’ up in this competition in 2023 and 2024, before reaching the semi-finals last season. Pioli has been replaced by Daniele Galloppa on an interim basis.

Mainz are taking this competition very seriously and, with home advantage as well as the woes of their opposition, they will fancy their chances of making it three from three.

Mainz vs Fiorentina tip: Mainz to win & both teams to score