Atletico Nacional vs Sao Paulo Preview & Prediction | 2025 Copa Libertadores | Round of 16

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Atletico Nacional managed to squeeze into the knockout stages of the Copa Libertadores, as they now take on Brazilian giants Sao Paulo this midweek.

Kick-off date/time:

How to watch on TV: UK – Not televised / US – Not televised

How to watch online: UK – Cannot be streamed / US – Fubo

Atletico Nacional vs Sao Paulo prediction

Atletico Nacional come into this one on the back of a comfortable 3-0 hammering of Alianza Lima in the Colombian Categoria Primera A Clausura at the weekend. They are now unbeaten in their last five matches across all competitions as they sit second in the table behind Atletico Junior domestically.

They now face a Sao Paulo side that, under the management of former Chelsea striker Hernan Crespo, most recently defeated Vitoria by two goals to nil in the Brazilian Serie A at the weekend. They finished top of Group D with four victories and two draws in their six matches, finishing above Paraguayan side Libertad.

Atletico Nacional have stumbled upon some improved form of late, but Sao Paulo have to be seen as favourites for both legs of this tie in the Libertadores round of 16.

Atletico Nacional vs Sao Paulo tip: Double chance – Sao Paulo to win or draw