Edinburgh will fancy their chances at BT Murrayfield since they have won their last 11 home games in all competitions. Dragons have only won one of their last five Pro14 games, so expect Edinburgh to comfortably win and claim an eighth victory of the campaign.
Both teams require a win to boost their play-off chances in their respective conferences. Home advantage will tip the balance in favour of Ospreys and Ulster have struggled away with only two wins from seven games.
Munster, who are the Conference A leaders, will look to continue their recent good form as they welcome the Southern Kings, who are bottom of Conference B.
Ireland beat Italy 54-7 last time out, and the team ranked second in the world should have little resistance from a plucky but inferior rugby side, even in Rome. Ireland have to mean business now, and will be aiming for maximum points because if England slip-up, points difference could come into play at the close of this competition.
This match at the Principality Stadium in Cardiff is now the most important for Eddie Jones’ England, who have already faced their biggest test and conquered it, by beating the reigning champions Ireland on the opening weekend of the tournament.
The match at Twickenham made for grim reading in a World Cup year for Les Bleus, who have now lost eight times out of their last nine competitive matches. Scotland, on the other hand, are a fantastic team to watch and are now reaching competitive levels with the world’s greatest.
Confidence must be sky high in the England camp right now, as they beat an Ireland side ranked above them in the world rankings, in Dublin, where the Irish had not lost for six years.
Italy’s flashes of offensive potency against Scotland were promising for a young team, probably the best Italian side for years, but they are still a league behind their competition in the Six Nations.
You can be sure that Joe Schmidt will be sending out a completely different Ireland side to face Scotland, as they have lost their most difficult test already at home to England.
The game in Dublin is being billed as the match of the tournament, and could be pivotal in determining who wins the Six Nations
Wales defeated France by one point in last year's Six Nations, and they will be boisterous heading into this game in Paris since they are undefeated in their last nine games.
Scotland will be confident of kick-starting their campaign with a win at Murrayfield, since Italy have lost their last 17 Six Nations games and finished bottom last year.
Scotland had high hopes coming into the Autumn Internationals but their performances may have fallen below those lofty expectations. Despite battering a poor Fiji side, losses to Wales and South Africa were hard to take for Scottish fans and players so they’ll be looking to finish strongly against Argentina.
Although most rugby fans have a soft spot for Fiji, it is hard to see them getting anything from a trip to Paris to face France. France have been victorious in all nine previous encounters with Fiji and have won all six games at home against them, not conceding a first-half try in that time.