Much has been made of how physically drained Anderson will be following his epic semi-final with John Isner but Djokovic's exertions in his own semi were arguably just as taxing given the physical nature of his incredible tussle with Nadal, not to mention the fact that the Serb was not afforded a rest day.
No two players have met more times in ATP history than Nadal and Djokovic, with this match representing the 52nd time the two tennis giants have collided. While the first of Friday's semi-finals will be an exhibition of huge serving, this promises to be a battle of endruance with long basement rallies in the offing.
We have two very different semi-finals on centre court on Friday and the first of those will see two huge servers do battle. There will not be many breaks of serve here and it is expected to be a tight battle decided by a tie-break or two. Isner will be the fresher of the two as Anderson's five-set quarter-final win over Federer will have used up a lot of physical and mental energy...
Nadal has yet to drop a set in this year's championship but this quarter-final will undoubtedly be his toughest test to date. Although the world number one made light work of Del Potro in Paris last month, this should be a more even contest on grass and it has every chance of going all the way to a deciding set.
It has been a tough road back to form for Djokovic following elbow surgery but there have been some positive signs during his path to this quarter-final and genuine belief that he is ready to challenge for major titles again. Nishikori is an opponent he has had the number of in recent years so the Serb has to be favoured to progress, but it will be an attritional battle between two players with a similar style and that could result in a nip-and-tuck contest.
Vesely will be full of confidence after some impressive wins so far and he certainly has the potential to cause Nadal some problems here. His powerful game may well earn him a set against the world number one, but anything more than that will be a surprise given how well Rafa has adapted to grass this year.
Federer has not lost any of his last 29 sets at Wimbledon and Mannarino has shown little to suggest that he will be the man to snap that streak. Mannarino has done well to get to this stage but he has faced relatively poor opposition so far and has not exactly found it easy as his five-set match with Medvedev in the third round showed.
Nadal eased through the opening match against Sela and he should do the same here against Kukushkin. While Nadal does not instil huge confidence when playing on grass...
Nothing but a straight sets victory for Federer is expected here. Lacko has been completely outclassed in the two previous matches they have played, and while he is playing some of his better tennis right now....
The draw has been relatively kind for Roger Federer as he returns to Wimbledon seeking his ninth title. Lajovic will be motivated to spring an upset, but lacks the weapons to really trouble Federer here....
Although a Nadal - Djokovic final would have made headlines, this is the climax that tennis purists would have hoped for before the tournament began. Thiem has been the second best player on clay for some time now and is the player most likely to dethrone Rafa at the tournament he has dominated for so long.
Possessing immense power, Del Potro is capable of hitting anyone off the court on his day but facing Nadal at the French Open is the ultimate test of a tennis player's credentials. The Argentine will need to play on the edge and go for the lines as anything less will not be good enough against the King of Clay, but sustaining such a level for the duration of a Grand Slam match is a feat few have managed in the past.
Thiem will be the heavy favourite here but he would be foolish to underestimate surprise-package Cecchinato, who has played some sensational tennis en route to this semi-final. The Italian fully deserved his victory over Djokovic in the last round and that will have given him even greater belief that he can keep his fairytale run going.
Although Nadal has won every set he has played at Roland-Garros this year, he has in fact had to dig deep against some inspired opponents but that will only serve him well as we reach the business end of the competition.