Barcelona are in the unusual position of not having won any of their last three league matches so there is pressure on them here. Spurs have shown some improvement of late but are missing some key players so this is a tough match to call, but both teams to score is a likely outcome.
After Inter overcame a 1-0 deficit to beat Tottenham last time out, they will be keen to follow up on that win and get a positive result here. Their form is strong at the moment having won their last four and they are slight favourites going into this one.
The very fact that PSG lost to Liverpool last time out will surely see them fired up for this one. They will be ultra motivated to win and win handsomely so that does not bode well for Crvena zvezda who could struggle to keep them at bay early in this match so it is likely to be a comfortable victory for the home side.
Much depends on which version of Galatasaray turns up as they are somewhat unpredictable but the onus will be on Porto to take the initiative at home. They are without Aboubakar but they should be able to expose a fragile Galatasaray defence and take the points here.
This match has the potential to be the most attractive match in the Champions League this week as Napoli and Liverpool are two of the most attacking teams in the competition. Expect goals and this one looks highly likely to see both teams scoring.
It has been a tough start to the season for both of these teams but they enjoyed wins in the league last weekend. Schalke will go to Moscow focusing on keeping things tight while 5 of Lokomotiv's last 6 games in this competition have seen under 2.5 goals so expect that trend to continue here.
This Monaco side is struggling badly so far this season in all competitions and they face a tough trip to Dortmund here. The hosts are in great form in the Bundesliga and they will relish this match and the opportunity to get another three points in what should be a lively and open game.
After some early season troubles, Atletico are hitting their stride now and they are playing some good football. Brugge are struggling to compete at this level as their recent form in this competition suggests so expect Atletico to win this comfortably and keep a clean sheet.
Roma are showing signs that they have finally clicked into gear this last week after a slow start and the win over Lazio especially will boost them. They are typically strong at home and will be confident of scoring a few against Plzen who are more than capable of scoring themselves.
It will be interesting to see how Shakhtar approach this game and whether they learned the lessons from their first match against Hoffenheim and also Lyon's tactics in their win over Man City. With over 2.5 goals in 6 of their last 7 matches in this competition, this game could easily follow suit.
The mood around Old Trafford is extremely negative right now and Valencia will know that if they can keep this tight in the first half, they can frustrate United's players and supporters. This has all the hallmarks of a low scoring game so expect a tight match at Old Trafford.
Juventus are relentless right now and just keep winning matches. They face a Young Boys team that is equally relentless in their own league but face a massive step up in class here and they will likely come unstuck in Italy with the hosts strongly favoured even without Cristiano Ronaldo.
City have to win this game after being shocked by Lyon in their opening match so there is some pressure on them here. Hoffenheim will provide them with a stern test, but they should have the overall quality to prevail and pick up their first win in the Champions League this season.
Real are slightly weakened coming into this game but they relish playing in this competition. The absence of Ramos and Bale does hamper them notably but they will still expect to score goals against CSKA, although they may not be a solid at the back without their talisman Sergio Ramos.