Man City's pursuit of the quadruple continues and this is another key match for them. Guardiola has rotated significantly in recent matches but he will field something close to his strongest team here and they should ultimately have far too much for an average Schalke side.
This match is arguably the toughest Round of 16 match to call as these two heavyweights collide. Their team selections for this first leg will give a big indication of how brave and ambitious each coach is feeling but it is hard to see too many goals in what could be a classically cagey first leg.
Lyon have picked up some impressive results at times this season with the win at Man City a particular highlight and they will take confidence from that. They will play primarily on the counter attack and they can cause this Barcelona defence problems so expect goals at both ends in this one.
Despite this being a first leg tie which are often cautious and cagey, the attacking nature of both these teams makes that unlikely. The fact Van Dijk is missing for Liverpool will weaken them significantly and Bayern are struggling to keep clean sheets so expect plenty of goals at Anfield.
Spurs beat Dortmund twice in the group stage of the 2017-18 campaign but the German side are a different beast under Favre this season. They boast the best defensive record in the Champions League so far and with both sides missing their top scorers, this could be a cagey first leg at Wembley.
Real Madrid are clear favourites for this match but Ajax are not the type of side to sit back, especially not at home. They have scored three or more goals in four of their last five Champions League games at home, while 14 of Real's last 16 matches in the competition have produced over two goals.
Porto were one of the standout performers of the group stage, winning five of their six games and scoring 15 goals. They only managed one clean sheet though and Roma have only failed to score in one of their last eight home games in the competition.
Having won 10 of his 11 games in charge, Manchester United caretaker boss Solskjaer faces his first European test. PSG are strong opponents but they are missing two key men in Neymar and Cavani.
Young Boys arguably have the Swiss league wrapped up already with their 19-point lead and they will be keen to put in a good display as they exit Europe. Juventus and Cristiano Ronaldo especially will be keen to maintain their relentless form, and expect the Italians to have too much quality.
Roma were outstanding when they hammered Plzen in Rome 5-0 earlier in the group stage but the two teams have taken different paths since then. The visitors are struggling with form without Dzeko, while Plzen are playing well right now so do not rule out the hosts springing a surprise.
United know that they have to win to have any chance of finishing top of the group but that will not really come into Mourinho's thoughts when selecting the team. He will rotate with the upcoming Liverpool game in mind and that will likely lead to a disjointed and low scoring match.
Shakhtar are playing in Kyiv this time due to the political unrest in Ukraine so that may upset their preparations somewhat. They are typically strong when playing at home but the change in venue may suit Lyon who will also enjoying playing on the counter and expect both teams to score here.
CSKA do not travel particularly well and after having lost at home to Plzen on matchday five, their confidence cannot be great as they head to the Bernabeu. Real are in fine form and even if they do rotate, they should still be able to canter to victory.
Both of these teams know only one way of playing and that is to attack. That could make Hoffenheim ripe for a heavy beating here as they can be a little naive at times, and Guardiola's wounded men will be determined to respond immediately to the defeat at Chelsea on Saturday.