Spurs come into this second leg with a 1-0 advantage but this will be a tough assignment at the Etihad. While they have won their last three games, they have all been at home, and this will be a completely different proposition against City who are formidable at home and should win on the evening.
Porto have it all to do in this second leg if they are to overcome this 0-2 deficit. They will take a more attacking approach and may well breach the Liverpool defence, but the visitors should hit them on the counter and grab vital away goals which will see them through to the semi-finals.
This match is finely poised after a 1-1 tie in the first leg and Juventus will be confident of taking control in this second leg. Ajax will play their natural game as they have to score in Turin, and while there should be goals at both ends, expect more Ronaldo magic to clinch it for Juve.
Despite coming into this match 1-0 down, United will approach this cautiously and aim to keep things tight before taking more risks later in the game. Barcelona should have too much savvy for them however as Messi and co will eventually pick them off and knock Solskjaer's men out.
Man Utd will take heart from their superb comeback win against Paris in the Round of 16, but their form since that match has been poor. They have lost three and were lucky to beat Watford which does not bode well when facing Barcelona, who can come away from Old Trafford with a first-leg advantage.
Ajax have picked up positive results against Bayern, Benfica and Real Madrid to reach this stage of the tournament so they will not be daunted in facing Juventus. They will approach this in their usual attacking style which should lead to an open and entertaining game with goals at both ends.
Man City have won their last three matches against Tottenham and they will be confident going into this tie. They will be desperate to get at least one away goal to take back to the Etihad and it should be one of the more open first-leg ties in the Champions League this midweek.
Liverpool will have been delighted with this draw compared to some of the other opponents they couild have had, especially after beating Porto 5-0 on aggregate in the Round of 16 last season. It may be closer this time around but Liverpool should have too much firepower for Porto at Anfield.
The first leg surprised many by ending goalless but it seems unlikely that it will happen again. That match was the only goalless draw Bayern have been involved in all season and this match will surely prove that the first leg was the exception to the rule so an open game is expected with both teams getting on the scoresheet.
Lyon will take some heart from their win at Man City earlier in the season where their counter attacking style paid dividends. This match could either be wide open with an early goal or be similarly cagey to the goalless first leg, but one would expect Barcelona to ultimately get the win.
Schalke come into this game needing to overcome a 3-2 first leg deficit but having lost their last four games and conceded 14 goals during that time. City will aim to kill this tie off early in the first half and then manage the game and victory in the second.
Juventus come into this second leg with a 0-2 deficit and they have a difficult task of penetrating one of the best defences in European football. Atletico are difficult to break down at the best of times and they will keep things tight to deny the home side, making a low-scoring affair likely.
United come into this second leg in Paris already 2-0 down from the first game and there may be some resignation that this is mission impossible for them. Solskjaer has to contend with even more absentees and this under-strength United side will struggle to deal with the in-form hosts.
The first leg was an entertaining match with both teams coming out of it relatively content. Porto grabbed an away goal and have some key players back for this game so they will be confident, but it promises to be another open match with goals at both ends of the pitch.