The visitors have more to play for here as they have a chance of qualifying for the Europa League while Schalke are confirmed in second place. The hosts however will be keen to bounce back from their derby loss at the weekend and should have too much for Lokomotiv even if they do rotate.
Monaco’s form remains woeful and even though Dortmund will likely rest some players here, they should still have far too much quality for what is essentially a combination of Monaco’s fringe and youth players. A comfortable away win and one to add to accumulators.
The game in Naples between these two sides was more cagey than many expected but this could be the complete opposite as in any scenario of the match, one team will be pushing hard for the win. As a result, goals at both ends looks to be a highly probable scenario.
The biggest issue for PSV has been transferring their stunning domestic form into the Champions League but that has meant them having to change their way of playing which they have struggled with. They will find it hard to stop a motivated Inter team who desperately need to win.
Galatasaray are not in particularly good form this season and while it is never an easy place to visit, Porto will not fear playing them. They are expected to rotate heavily for this match with nothing on the line for them so that may allow the hosts to get a morale-boosting result here.
Paris completely dominated Crvena Zvezda when they met at home but they will know that the Serbian team are a completely different proposition at home. That said, with victory imperative for Paris, they should have enough motivation to win this one comfortably and rack up the goals.
There is a chance that Atletico could rest some players as they do have various injury concerns but they have plenty of quality options. Brugge on the other hand are not playing well and are missing players too, so there is every likelihood that Atletico overwhelm them here.
So much depends on the team which Barca field for this match as they could rest plenty of their star men for this game. Spurs are playing well but may have half an eye on what is happening in the other game which could condition how they approach this. Either way, expect goals at the Camp Nou.
Tottenham have only won one of their last six Champions League games but they go into this one in good form and have not failed to score in the competition for over two years. Inter have kept just one clean sheet in their last 11 away Champions League games so expect both teams to score.
Barcelona are already through to the last 16 but they will want to seal top spot in the group. The La Liga champions are in good form in Europe, unlike PSV, but the hosts have scored in three of their four group games so we could see both sides getting on the scoresheet here.
Liverpool won 3-2 in a thrilling reverse fixture at Anfield two months ago and another high-scoring game can be expected. Liverpool have conceded 14 goals in their last seven away Champions League games and with Neymar and Mbappe likely to return for PSG, goals are virtually guaranteed.
These two sides shared the points in Gelsenkirchen in September but Porto have won their last eight games in all competitions and are also unbeaten in nine at home. Schalke have only won two of their last ten away games overall so the hosts should come out on top in this contest.
Crvena Zvezda earned a draw with Napoli in the reverse fixture but their two away games in Group C have ended in 6-1 and 4-0 defeats. Insigne, who has scored in each of Napoli's last five home games in the competition, will therefore be licking his lips and has to be fancied for first goalscorer.
Galatasaray ran out 3-0 winners when these two sides met in Istanbul but it could well be a very different story in Moscow. Terim's men have a pretty dire away record in the Champions League and although Lokomotiv lost at home to Schalke and Porto, they should get something from this one.