After a difficult start to the season, United have shown signs of improvement and they are enjoying playing away from home right now. Young Boys will look to keep things tight and that could lead to something of a stalemate so do not expect many goals in this one.
This is a big game for both these teams as they will likely be scrapping for third spot with Real Madrid and Roma being the other two teams in this group. CSKA were excellent on their travels last season and will fancy their chances of getting another victory in the Czech Republic here.
These two teams have started their domestic seasons in contrasting form as Valencia have struggled badly so far while Juventus have a 100% record in Serie A despite not playing that well. The Italians mean business this season and they will want to make a statement in this opening match.
Shakhtar have plenty of experience of playing in the Champions League and they host Hoffenheim who are making their very first appearance in the Champions League. Leipzig were similar last season and the euphoria affected their tactics somewhat and this could be a reality check for the Germans.
A big task for Roma here as they have to raise their game notably if they are to trouble Real Madrid at the Bernabeu. The hosts begin their Champions League defence without Cristiano Ronaldo, but the front men are relishing the opportunity to prove they can live without him so expect goals here.
Lyon have not started the season particularly well which does not bode well as they face an in-form Man City side. At the Etihad, City are ruthless and while Lyon have some good attacking options and could cause them some problems defensively, City should have far too much for them here.
Bayern's goalscoring record in the Champions League is superb and their matches are extremely open. 15 of their last 16 matches in the Champions League have seen over 2.5 goals and Benfica will play their part in ensuring this one follows suit in what should be an entertaining affair.
AEK will travel to Amsterdam on a major high having reached this stage but they will be keen to avoid defeat more than anything else. Combined with Ajax's strong start and excellent defensive record so far this season, this could be a relatively cagey match with few goals.
Spurs travel to Milan in poor form having lost their last two matches and star striker Harry Kane is in the spotlight as his goal drought continues. Inter are not playing that well themselves and with the firepower on show, there could be plenty of goals.
Schalke's start to the season has been woeful so far having lost all three league matches and now they face a tough opener in the Champions League. Porto are not at their best but are accustomed to playing in this competition, so will fancy returning to Portugal with at least a point, if not three.
Bizarrely, both of these teams are struggling for form right now despite possessing plenty of quality in their squads and making some big signings this summer. Monaco's Champions League form of late has been poor and expect Simeone's men to bounce back with a victory here.
This promises to be a fascinating and entertaining game if both teams play their natural style. The goals were flowing for both sides in this competition last season and despite this being the first match of the group stages, expect that to continue with goals at both ends.
Galatasaray have a poor record in recent times in the Champions League while Lokomotiv have endured a tough start to their league season. The hosts will have to take the initiative here and they look to have the edge in quality on paper so they could edge a narrow victory.
There will be plenty of anticipation around Crvena zvezda's first ever Champions League group stage match as they welcome Napoli to Belgrade. Napoli will play their usual attacking style despite not having a great away record in this competition and that should make for a high tempo and open game.