There are many facets to Lionel Messi's game, but his goalscoring frequency is up there with the very best in the history of the game. His Champions League record is staggering, and over the last decade the Argentine and his rival Cristiano Ronaldo have raised the bar.
Cristiano Ronaldo's extraordinary goalscoring exploits rightly get the attention they deserve, and his strike-rate in the Champions League is nothing short of breathtaking. He is the tournament's all-time leading scorer and shows no sign of slowing down.
The first leg surprised many by ending goalless but it seems unlikely that it will happen again. That match was the only goalless draw Bayern have been involved in all season and this match will surely prove that the first leg was the exception to the rule so an open game is expected with both teams getting on the scoresheet.
Lyon will take some heart from their win at Man City earlier in the season where their counter attacking style paid dividends. This match could either be wide open with an early goal or be similarly cagey to the goalless first leg, but one would expect Barcelona to ultimately get the win.
Schalke come into this game needing to overcome a 3-2 first leg deficit but having lost their last four games and conceded 14 goals during that time. City will aim to kill this tie off early in the first half and then manage the game and victory in the second.
Juventus come into this second leg with a 0-2 deficit and they have a difficult task of penetrating one of the best defences in European football. Atletico are difficult to break down at the best of times and they will keep things tight to deny the home side, making a low-scoring affair likely.
United come into this second leg in Paris already 2-0 down from the first game and there may be some resignation that this is mission impossible for them. Solskjaer has to contend with even more absentees and this under-strength United side will struggle to deal with the in-form hosts.
The first leg was an entertaining match with both teams coming out of it relatively content. Porto grabbed an away goal and have some key players back for this game so they will be confident, but it promises to be another open match with goals at both ends of the pitch.
Despite a tough run of recent results, Real Madrid return to Champions League action where they will be confident of getting back to winning ways in their favourite competition. Ajax have to go all out to attack the hosts and while they may score, that should play into Real's hands.
Neither of these teams come into this second leg in good form so both will be keen to get a positive result to build confidence even though the tie appears over at 3-0. That should lead to a relatively open match and both teams to score looks like a strong possibility in Dortmund.
Confidence at Chelsea is clearly pretty low at the moment and the players seem to lack belief in Sarri and his tactics. They will no doubt rise to the occasion at Wembley but it is difficult to see them bridging the gap against this City team that beat them 6-0 in the league two weeks ago.
Man City's pursuit of the quadruple continues and this is another key match for them. Guardiola has rotated significantly in recent matches but he will field something close to his strongest team here and they should ultimately have far too much for an average Schalke side.
This match is arguably the toughest Round of 16 match to call as these two heavyweights collide. Their team selections for this first leg will give a big indication of how brave and ambitious each coach is feeling but it is hard to see too many goals in what could be a classically cagey first leg.
Lyon have picked up some impressive results at times this season with the win at Man City a particular highlight and they will take confidence from that. They will play primarily on the counter attack and they can cause this Barcelona defence problems so expect goals at both ends in this one.